||Abstract In this thesis, we focus on the determinants of life expectancy at birth in Mexico’s federative entities. The aim is to consider three selected variables determining life expectancy – health care expenditures, unemployment, and school enrolment. We use panel data for up to 21 year period (1994-2014) controlling for already well-examined determinants (vaccination coverage, literacy rate, and infant mortality rate). Fixed e↵ect or random e↵ect estimation is applied according to the hypo- theses. Robustness test is performed using Principal Component Analysis including proxies of the main four groups of variables a↵ecting life expect- ancy – economic, social, health care and environmental. The results suggest a positive e↵ect of health care expenditures on life ex- pectancy at birth. However, a signiﬁcant e↵ect of unemployment or primary school enrolment is not conﬁrmed. Principal Component Analysis suggests the existence of additional determinant related to health care expenditures a↵ecting life expectancy. This thesis contributes to the debate on discussed variables (healthcare expenditures, unemployment, and primary school enrollment) related to life expectancy. We also extend the limited research on life expectancy in Mexico and Latin America.